European Cytokine Network
MENULck is involved in interleukin-2 induced proliferation but not cell survival in human T cells through a MAP kinase-independent pathway. Volume 11, numéro 2, June 2000
Illustrations
Institute for Medical Microbiology and Immunology, Panum Institute, Building 22.5, Blegdamsvej 3,
DK-2200 Copenhagen N, Denmark.
- Page(s) : 225-31
- Année de parution : 2000
INTRODUCTION The association of the Src family protein tyrosine kinase (PTK) Lck with the interleukin-2 receptor (IL-2R) beta-chain has been reported by several groups [1, 2]. Lck interacts with the acidic domain of IL-2R beta-chain, and this interaction is necessary for Lck activation upon IL-2 stimulation [1-6]. The serine-rich region of IL-2R beta-chain is also necessary for Lck activation and the induction of the nuclear proto-oncogenes [...]