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European Cytokine Network

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Activation of caspase-3 by interferon alpha causes interleukin-16 secretion but fails to modulate activation induced cell death Volume 12, numéro 3, September 2001

Auteurs
Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
  • Page(s) : 478-86
  • Année de parution : 2001

INTRODUCTION Interferon alpha (IFN-alpha) is a highly pleiotropic cytokine that was initially described for its ability to interfere with viral replication [1]. It has been shown to be useful in a variety of diseases of diverse pathogenesis including chronic viral hepatitis, chronic myelogenous leukemia, hairy cell leukemia and papillomas [2]. Despite its clinical success, the detailed mechanisms of action have not yet been well defined. [...]