European Cytokine Network
MENUInterleukin-18 stimulates HIV-1 replication in a T-cell line. Volume 11, numéro 1, March 2000
Illustrations
Universitätsklinik Frankfurt, Medizinische Klinik III, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.
- Mots-clés : AIDS, interleukin-18, interferon, IGIF, anti IL-18 antibodies, baculovirus.
- Page(s) : 47-52
- Année de parution : 2000
INTRODUCTION Interleukin-18 (IL-18) was described recently as interferon-gamma inducing factor (IGIF) [1]. Apart from its function as an essential co-factor for IFN-gamma induction, several other, even more pivotal capacities of this new cytokine can be defined in the murine and human system. IL-18 was demonstrated to enhance the activity of Th1 type T-cells and NK cells [2, 3]. In addition to Th1 type cytokines the expression of TNF-alpha [...]