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Interleukin-18 stimulates HIV-1 replication in a T-cell line. Volume 11, numéro 1, March 2000

Auteurs
Universitätsklinik Frankfurt, Medizinische Klinik III, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.

INTRODUCTION Interleukin-18 (IL-18) was described recently as interferon-gamma inducing factor (IGIF) [1]. Apart from its function as an essential co-factor for IFN-gamma induction, several other, even more pivotal capacities of this new cytokine can be defined in the murine and human system. IL-18 was demonstrated to enhance the activity of Th1 type T-cells and NK cells [2, 3]. In addition to Th1 type cytokines the expression of TNF-alpha [...]