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Hepatocyte growth factor plasma levels after myocardial infarction are not affected by recombinant tissue-type plasminogen-activator therapy Volume 11, numéro 1, March 2000

Auteurs
Department of Gastroenterology, University Hospital Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria. Herbert.Tilg@uibk.ac.at

INTRODUCTION Hepatocyte growth factor is a multifunctional, pleiotropic cytokine composed of an alpha- (69 kDa) and beta-subunit (34 kDa) linked by a disulfide bond. HGF is produced mainly by mesenchymal cells such as fibroblasts and smooth muscle cells and acts predominantly on epithelial and endothelial cells. HGF is the most potent mitogen for mature parenchymal hepatocytes in primary culture and seems to be a hepatotrophic factor that [...]