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Expression of thrombopoietin (TPO) by the umbilical vein endothelial cell. Volume 12, numéro 2, June 2001

Auteurs
Laboratoire de cytogénétique, Institut Pasteur du Maroc, BP 120, 1, place Aboukalem-Ezzahraoui, Casablanca, Maroc.
  • Page(s) : 268-73
  • Année de parution : 2001

INTRODUCTION Thrombopoietin (TPO) is a primary regulator of megakaryocytopoiesis. Impairing either TPO production or the expression of the TPO receptor in mice leads to reduction of platelet production to about 15% of normal basal levels in peripheral blood [1, 2]. Overexpression of TPO in mice or administration of recombinant TPO to animals or humans leads to a dose-dependent increase in the platelet counts [3-6]. TPO is not only an essential [...]