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Hematopoietic growth factors in patients receiving intensive chemotherapy for malignant disorders studies of granulocyte-colony stimulating factor (G-CSF), granulocyte monocyte-colony stimulating factor (GM-CSF), interleukin-3 and Flt3 ligand (Flt3L). Volume 12, numéro 2, June 2001

Auteurs
Department of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway.
  • Page(s) : 231-8
  • Année de parution : 2001

INTRODUCTION Hematopoiesis is regulated by a wide range of soluble mediators that interact through the local cytokine network of the bone marrow microenvironment [1, 2]. This local network regulates proliferation and differentiation of normal progenitor cells into mature forms [1], and is also important for the regulation of proliferation, differentiation and survival in leukemic hematopoiesis [2]. The mediators granulocyte-macrophage colony-stimulating [...]