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European Cytokine Network

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Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases. Volume 9, numéro 4, December 1998

Auteurs
Clinical Immunology Unit, University Hospital, 24, rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland. Tel: (+41) 22 372 93 76, Fax: (+41) 22 372 93 69.
  • Page(s) : 663-8
  • Année de parution : 1999

INTRODUCTION In chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis, infiltrating cells as well as resident tissue cells are in close proximity at the inflammatory site. This implies that, in addition to soluble factors, cells such as T lymphocytes, monocyte/macrophages can communicate by direct cell-cell contact. Our recent results demonstrated that this biological mechanism, i.e., cell-cell [...]