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GP130 cytokines, interferon, survival and proliferation of human myeloma cells Volume 8, numéro 3, September 1997

Auteur
  • Page(s) : 323
  • Année de parution : 1997

Multiple myeloma is a B cell neoplasia that affects the late stage of B cell differentiation: the plasma cells. This disease develops first in the bone marrow and the tumoral clone progressively destroys the bone marrow environment, and in particular the bone tissue. The tumoral clone exhibits extensive somatic mutations in the VH and VL Ig genes with no intraclonal variations. This shows evidence for antigen selection during [...]