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Effects of murine recombinant interleukin-10 on the inflammatory disease of rats transgenic for HLA-B27 and human 2-microglobulin Volume 9, numéro 2, June 1998

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INTRODUCTION The mucosal lesions in Crohn's disease (CD) and ulcerative colitis (UC) are characterized by an infiltration with inflammatory cells predominantly represented by neutrophils, macrophages and lymphocytes [1]. Phenotypic and limited functional studies indicate that macrophages present in these lesions are activated to produce proinflammatory mediators, oxygen free radicals and proteolytic enzymes [2-4]. [...]