European Cytokine Network
MENUEffects of murine recombinant interleukin-10 on the inflammatory disease of rats transgenic for HLA-B27 and human 2-microglobulin Volume 9, numéro 2, June 1998
Illustrations
V. Bertrand, S. Quéré, R. Guimbaud, P. Sogni, L. Chauvelot-Moachon, M. Tulliez, D. Lamarque, J. Charreire, J.P. Giroud, D. Couturier, S. Chaussade, M. Breban
- Mots-clés : HLA-B27transgenic rats, interferon-, IL-10, inducible NO synthase, inflammatory bowel disease.
- Page(s) : 161-70
- Année de parution : 1998
INTRODUCTION The mucosal lesions in Crohn's disease (CD) and ulcerative colitis (UC) are characterized by an infiltration with inflammatory cells predominantly represented by neutrophils, macrophages and lymphocytes [1]. Phenotypic and limited functional studies indicate that macrophages present in these lesions are activated to produce proinflammatory mediators, oxygen free radicals and proteolytic enzymes [2-4]. [...]