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Mice lacking alpha2-macroglobulin show an increased host defense against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock Volume 13, numéro 1, March 2002

Auteurs
Department of Molecular Biology, KL Ledeganckstraat 35, B-9000 Ghent, Belgium.
  • Page(s) : 86-91
  • Année de parution : 2002

INTRODUCTION Septic shock due to a bacterial infection is the main cause of mortality in the intensive care unit [1]. Almost any bacterium can cause septic shock, but Escherichia coli and Klebsiella pneumoniae are among the most frequent culture isolates [2]. Unfortunately, the emergence of multidrug-resistant bacteria has made the treatment of these patients quite problematic [3]. Septic shock is the result of a very complex sequence [...]