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European Cytokine Network

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Estradiol and raloxifene decrease the formation of multinucleate cells in human bone marrow cultures Volume 13, numéro 1, March 2002

Auteurs
INSERM U. 349, Lariboisière Hospital, 2, rue Ambroise-Paré, 75475 Paris Cedex 10 France.
  • Page(s) : 39-45
  • Année de parution : 2002

INTRODUCTION The increased bone resorption that occurs in postmenopausal women is due to a lack of estrogen (E2), and can be prevented by estrogen replacement therapy [1]. The mechanism by which estrogen acts on bone is not fully understood, but it involves inhibition of the proliferation and differentiation of osteoclast precursors [2]. It has been proposed that the effects of estrogen on osteoclast differentiation are mediated by interactions [...]