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Caspase-1 levels in biological fluids from patients with multiple sclerosis and from patients with other neurological and non-neurological diseases Volume 13, numéro 1, March 2002

Auteurs
Foundation Neurological Institute C. Mondino, via Palestro 3, I-27100 Pavia, Italy.
  • Page(s) : 99-103
  • Année de parution : 2002

INTRODUCTION Caspase-1, formely IL-1beta converting enzyme (ICE) [1], belongs to a family of proteases (caspases), which cleaves substrates at sites with aspartate in the P1 position. Caspases can activate a signalling cascade that leads to cell apoptosis [2]. However, caspase-1 is more involved in inflammation than in apoptosis. Caspase-1 yields to the active form of IL-1beta [1], and activates the so-called IFN-gamma-inducing factor [...]