European Cytokine Network
MENUCaspase-1 levels in biological fluids from patients with multiple sclerosis and from patients with other neurological and non-neurological diseases Volume 13, numéro 1, March 2002
Illustrations
Diego Franciotta, Gianvito Martino, Elisabetta Zardini, Roberto Furlan, Roberto Bergamaschi, Maira Gironi, Alessandra Bergami, Giovanna Angelini, Fabrizio De Benedetti, Patrizia Pignatti, Gianna Moscato, Vittorio Cosi
Foundation Neurological Institute C. Mondino, via Palestro 3, I-27100 Pavia, Italy.
- Page(s) : 99-103
- Année de parution : 2002
INTRODUCTION Caspase-1, formely IL-1beta converting enzyme (ICE) [1], belongs to a family of proteases (caspases), which cleaves substrates at sites with aspartate in the P1 position. Caspases can activate a signalling cascade that leads to cell apoptosis [2]. However, caspase-1 is more involved in inflammation than in apoptosis. Caspase-1 yields to the active form of IL-1beta [1], and activates the so-called IFN-gamma-inducing factor [...]