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European Cytokine Network

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Interferon-beta (INF-b) antibodies in interferon-b1a- and interferon-b1b-treated multiple sclerosis patients. Prevalence, kinetics, cross-reactivity, and factors enhancing interferon-b immunogenicity in vivo. Volume 12, numéro 1, March 2001

Auteurs
Department of Neurological & Psychiatrical Sciences, Second Neurological Clinic, Geriatric Hospital, Via E. Vendramini 7, 35137 Padova, Italy.
  • Page(s) : 56-61
  • Année de parution : 2001

INTRODUCTION A complex, but still undefined network of naturally occurring soluble factors, including cytokines, soluble cytokine receptors, cytokine receptor antagonists, and anti-cytokine antibodies regulates the activation of the immune system. Autoantibodies to cytokines are only occasionally found in the serum of normal healthy individuals, but they are frequently detected at high titers in the serum of patients with autoimmune and [...]