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Expression of CD1a and CD86 on scleroderma Langerhans cells

European Journal of Dermatology. Volume 18, Numéro 1, 50-4, January-February 2008, Investigative report

DOI : 10.1684/ejd.2008.0310

Summary

Auteur(s) : Yong Xie, Xiaoyong Zhang, Yuji Inoue, Shouji Wakasugi, Takamitsu Makino, Hironobu Ihn , Department of Dermatology & Plastic and Reconstructive Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

Illustrations

Figure 1 Immunohistochemical staining for CD1a and CD86 positive cells (brown) in dermis of scleroderma and normal skin (× 400). A) CD1a was sparsely expressed in normal skin; B) CD1a was strongly expressed in localized scleroderma. C) CD1a was expressed in SSc. D) normal skin: no CD86 immunoreactivity. E) CD86 was expressed in localized scleroderma. (F) CD86 was expressed infrequently in SSc.

Figure 2 Immunohistochemical staining for CD1a and CD86 positive cells (brown) in the epidermis of scleroderma and normal skin (× 400). A) CD1a was expressed in normal skin; B) CD1a was strongly expressed in localized scleroderma. C) CD1a was expressed in SSc. D) normal skin: no CD86 immunoreactivity. E) CD86 was expressed infrequently in localized scleroderma. F) CD86 was not expressed in SSc.

Figure 3 Immunohistochemical staining for CD208 positive cells (brown) in dermis of localized scleroderma and normal skin. A) CD208 was hardly detected in normal skin dermis, but CD208 was expressed in the cellular infiltration of localized scleroderma skin sections (B).