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Editorial

Magnesium Research. Volume 18, Numéro 4, 205-6, december 2005, Editorial

Auteur(s) : Jean Durlach , Editor-in-Chief, Magnesium Research.

ARTICLE

Auteur(s) : Jean Durlach¹

Editor-in-Chief, Magnesium Research

This last issue of volume 18 of Magnesium Research 2005, covering a large span of new data, concerns many disciplines and originates from many parts of the world.It includes experimental and clinical studies in biology, cardiology, endocrinology, internal medicine, membranology, neurology, nutrition, pharmacology, therapeutics and toxicology.

1. Four experimental papers are presented

K. Kisters et al. (Herne, Germany) showed a decreased intracellular magnesium and phosphate concentration in smooth muscle cells of spontaneously hypertensive rats, possibly due to a membrane defect or to an altered ATP metabolism which may be responsible in the pathogenesis of primary hypertension.

C. Coudray et al. (Theix-Clermont-Ferrand, France) studied the magnesium bioavailability of ten organic and inorganic magnesium salts, in magnesium-depleted rats using a stable isotope approach: ²⁶Mg is sufficiently bioavailable from the ten Mg salts studied.

The first study by F. Sabbagh et al. (Paris, France) evaluated endothelial cell activation and tissue remodelling in the lungs in mice fed severe Mg-deficient diet. Immunocytochemical evaluations did not reveal endothelial cell activation in mouse lung. However a latent inflammatory status of the lung can be hypothesized which might be expressed following the stresses of transplantation.

The second study by F. Sabbagh et al. (Paris, France) concerned the effect of Mg deficiency on endothelial cell allogeneic activation in a model of isolated perfused mouse lung. Hypomagnesemia in donors does not constitute an additional risk for allograft outcome and might allow to lighten the recipient’s immunosuppressive treatment.

2. Next come four original clinical papers

P. Kozielec et al. (Szczecin, Poland) assessed serum ionized magnesium levels in patients with ischemic heart diseases and hypertension. Slightly lower mean serum ionized Mg concentration was found in the group with hypertension alone.

K. Pasternak et al. (Lublin, Poland) stressed the importance of normovolemic hemodilution in determination of Mg blood levels disorders during extra corporeal circulation.

A. Korycinska et al. (Lublin, Poland) showed that extracorporeal circulation was associated with a decrease of Mg concentration in the blood and an increase of lymphocyte apoptosis intensity. The decrease of Mg blood concentration may increase the degree of lymphocyte apoptosis.

M. Iskra et al. (Poznan, Poland) investigated 54 men with chronic ischemia of the lower limbs: the mean value of the serum Mg concentrations were found significantly lower.

3. Two review papers follow next

H. Rubin (Berkeley, CA, USA) proposed the membrane, Mg, mitosis (MMM) model of cell proliferation control with a major role of Mg in protein activation.

K. Ueshima (Morioka, Japan) reviewed the links between Mg and ischemic heart diseases. Dietary Mg supplementation may be considered as a preventive element in atherosclerosis and ischemic heart disease.

4. Selected abstracts of the last issues of the Journal of Elementology, the Forthcoming Contents, the authors and key words indexes complete the last 2005 issue of our quarterly international journal Magnesium Research.

1 President, SDRM.