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In vitro application of endotoxin enhances nitric oxide production in thoracic aortas from Mg-deficient rats

Magnesium Research. Volume 18, Numéro 3, 155-62, September 2005, original article

Summary

Auteur(s) : Atsushi Miyamoto, Hiroshi Moriki, Shigeru Ishiguro, Akira Nishio , Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan.

Illustrations

Figure 1 NO production from the thoracic aorta during 6 h incubation in vitro with and without endotoxin (lipopolysaccharide: LPS).: control rats; : Mg-deficient rats (n = 5 in each group).*p < 0.05 compared with corresponding LPS minus.**p < 0.05 compared with corresponding control rat.

Figure 2 Effect of endothelium-denudation on NO production from thoracic aortas of Mg-deficient rats (n = 5).

Figure 3 Effect of a selective iNOS inhibitor (1400W) on NO production from thoracic aortas of control and Mg-deficient rats.: control rats; : Mg-deficient rats (n = 6 in each group).*p < 0.05 compared with corresponding control rat.

Figure 4 Effect of antibodies to IgG_2a, TLR4 and CD14 on endotoxin (lipopolysaccharide: LPS) (1 μg/mL)-induced NO production from thoracic aortas of control () and Mg-deficient () rats (n = 4 in each group).*p < 0.05 compared with corresponding control rat.**p < 0.05 compared with corresponding anti-IgG_2a.