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HSV1-derived vectors: a powerful and flexible system for genes transfers Volume 11, issue 5, septembre-octobre 2007

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Université Lyon 1, 69003 Lyon, CNRS, UMR5534, Centre de génétique moléculaire et cellulaire, 69622 Villeurbanne

Amplicons are non-integrative defective herpes simplex type 1 (HSV1) derived vectors. Their genomes are entirely free of viral genes, making these vectors non toxic for infected cells and non pathogenic for inoculated animals. In addition, amplicon vectors possess the unique property of delivering up to 150 kbp of foreign DNA. These characteristics make amplicon vectors one of the most powerful and promising viral vectors for gene transfer. This review illustrates several interesting applications using amplicon vectors, as well as problems that need to be resolved in order to obtain stable and physiological transgene expression.