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BK-virus and pathophysiology of associated diseases Volume 23, issue 1, Janvier-Février 2019

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Authors
1 Hôpitaux universitaires de Strasbourg,
Laboratoire de virologie,
3, rue Koeberlé,
67000 Strasbourg, France
2 Université de Strasbourg,
Inserm, UMR-S 1109,
3, rue Koeberlé,
67000 Strasbourg, France
* Tirés à part

BK virus (BKV) is a widely distributed polyomavirus in the world population. It is the causative agent of BKV-associated nephropathy in kidney transplant recipients and hemorrhagic cystitis in bone marrow transplant patients. To date, there is no specific antiviral treatment against BKV. A better understanding of the pathophysiology of BKV-associated diseases, especially in immunocompromised patients, may contribute to the development of novel preventive and therapeutic strategies. After a detailed description of the genomic characteristics of the virus, its replication cycle and available model systems, the pathophysiological and immune mechanisms involved in BKV infection are developed and discussed in this review.

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