Laboratory of Dendritic Cell Immunobiology,
25-26 rue du Docteur-Roux,
During evolution, organisms were confronted with different environmental pressures leading to selective evolution of different intracellular pathways. Autophagy, an ancestral cellular mechanism involved in cell homeostasis and survival, provides an interesting example of this biologic concept. The constant dialog between viral infections and mechanisms of host protection has scripted the evolving relationship between autophagy and viruses, with some infectious agents being controlled by autophagy; whereas others, perhaps more opportunistic viruses, have adapted to manipulate autophagy for their own benefit.