JLE

Virologie

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Mitochondrial toxicity of nucleoside analogues Volume 8, issue 4, juillet-août 2004

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Authors
Laboratoire de virologie, hôpital La Pitié-Salpêtrière, Laboratoire de virologie du CERVI, UPRES EA 2387, 83, boulevard de l’Hôpital, 75651 Paris cedex 13, Laboratoire de Virologie, hôpital Necker, Paris, Service d’immunologie hématologie pédiatrique, hôpital Necker, Paris

A long term exposure to some nucleoside reverse transcriptase inhibitors induces a severe depletion of mitochondrial DNA (mtDNA) throughout the inhibition of polymerase γ. Even though the mtDNA depletion has been correlated to the incidence of side effects in several studies, the mechanisms underlying this phenomenon are still unclear. The mtDNA depletion may not be responsible for the rise of mitochondrial toxicity but would provide a good toxicity marker because of the ease of its exploration. In order to evaluate this marker, there is a need determine in which tissue, at what time and with which tool quantify mtDNA.