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The family Anelloviridae: TTV virus and related types Volume 14, issue 1, janvier-février 2010

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Authors
Établissement français du sang Alpes-Méditerranée, 149, boulevard Baille, 13005 Marseille, France, UMR CNRS 6578, équipe « émergence et co-évolution virale », Université de la Méditerranée, CTRS « Infectiopôle Sud », 27, boulevard Jean-Moulin, 13005 Marseille, France

Since the identification of the prototype TTV in 1997, the diversity of members belonging to the family Anelloviridae identified in human and some animal species kept on increasing. At the same time, data regarding their natural history remain relatively limited. These viruses exhibit an extreme genetic diversity and a high prevalence in various populations, progressively demonstrated by the characterisation of full-length genomes and the optimisation of detection systems. Such unusual properties made the various studies intended to elucidate the implication of Anelloviridae in host’s health difficult to develop, their biology being still poorly understood in absence of a robust culture system. These viruses have been identified in the blood and in multiple biological locations\; they are probably remarkable examples of co-existence and co-evolution with their human and animal hosts.