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Host cell factors in HIV replication: partners and opponents Volume 17, issue 3, Mai-Juin 2013

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Authors
Université Paris-Diderot, Inserm U941, Institut universitaire d’hématologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France

Cycles of virus replication within the cell are often presented in a simplistic manner, viruses being considered as intracellular parasites simply diverting the cellular machinery for their own benefit. Accumulated knowledge on the relationship between the human immunodeficiency virus (HIV) and host cells illustrate the complexity of these relationships. Some cellular factors are partners of the virus and are essential for the proper performance of the multiplication cycle, whereas other factors are adversaries with antiviral activity, called restriction factors. This review aims to give an overview of these partners and opponents.