Lipid profile of patients on chronic hemodialysis (Morocco)

Samira Elmachtani Idrissi; Abdellah Dami; Sanae Bouhsain; Zohra Ouzzif; Toufik Aatif; Mustapha El mezouari; Mohammed Asseraji; Omar Maoujoud; Mustapha El allam; Zouhir Oualim; Saida Tellal

doi:10.1684/san.2011.0233



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Lipid profile of patients on chronic hemodialysis (Morocco)
Cahiers d'études et de recherches francophones / Santé . Volume 21, Number 1, 27-31, Janvier-Mars 2011, Études originales
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Author(s) : Samira Elmachtani Idrissi, Abdellah Dami, Sanae Bouhsain, Zohra Ouzzif, Toufik Aatif, Mustapha El mezouari, Mohammed Asseraji, Omar Maoujoud, Mustapha El allam, Zouhir Oualim, Saida Tellal
Summary : Introduction : Patients with end-stage renal disease (ESRD) receiving chronic hemodialysis show a high incidence and prevalence of cardiovascular disease of multifactorial etiology and an association between dyslipidemia and accelerated atherosclerosis. Objective : Our aim was to study lipid profiles in ESRD patients receiving dialysis regularly at our hospital (Morocco). Subjects and methods : The patient population consisted of 30 ESRD patients on maintenance haemodialysis. Matched control subjects were recruited among healthy normolipidemic patients. Concentrations of triglycerides (TG), total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C) and low-density-lipoprotein cholesterol (LDL-C) were measured. The atherogenic index (AI \= TC/HDL-C ratio) was calculated. Results : The TG, the HDL-C levels and atherogenic index were significantly higher in groups of hemodialysis patients. We saw no increase in the levels of TC and LDL-C. The prevalence of dyslipidemia in hemodialysis group was high (80%). The most frequent lipid alterations were decreased HDL-C (70%), increased TG (33,3%) and increased LDL-C (23,3%)\; 50% of ESRD patients have more than two different dyslipidemic findings. AI was higher (≥ 5) in 33,3% of cases. Conclusion : The prevalence of dyslipidemia is higher than normal in ESRD patients on maintenance hemodialysis. Classically, these patients have had low levels of HDL-C and elevated TG levels. Strict control of dyslipidemia should be part of the cardiovascular risk prevention strategy in this population.
Keywords : atherosclerosis, dyslipidemia, hemodialysis, lipoproteins, Morocco