Epidemiological and clinical characteristics of intestinal microsporidiosis

Sonia Anane; H Attouchi; E Kaouech; S Belhadj; T Ben Chaabane; N Ben Abdallah; T Ben Othman; A Samoud; M Ben Hriz; K Kallel; E Chaker

doi:10.1684/san.2010.0188



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Epidemiological and clinical characteristics of intestinal microsporidiosis
Cahiers d'études et de recherches francophones / Santé . Volume 20, Number 1, 21-9, janvier-février-mars 2010, Étude originale
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Author(s) : Sonia Anane, H Attouchi, E Kaouech, S Belhadj, T Ben Chaabane, N Ben Abdallah, T Ben Othman, A Samoud, M Ben Hriz, K Kallel, E Chaker
Summary : IntroductionIntestinal microsporidiosis is an opportunistic parasitological infection affecting mainly immunocompromised patients, particularly those infected with HIV. Purpose: The purpose of this study was to analyse the epidemiological and clinical characteristics of intestinal microsporidiosis and the treatments available for it. Materialand methods: This retrospective study examined records collected over a 13-year period (from January 1995 through December 2007). It included 572 immunocompromised patients (279 HIV-infected patients and 293 without HIV infection) with symptoms suggesting intestinal microsporidiosis. All were tested systematically for microsporidia spores by modified (Weber's) Trichrome staining. Results: Fourteen patients (10men, 4women) were diagnosed with intestinal microsporidiosis, for a prevalence of 2.4% overall, 3.6% in HIV-infected patients and 1.4% in those without HIV infection. Intestinalmicrosporidiosis affected 10 HIV-infected patients, 70% of whom had a CD4 count <\;100 cells/mm ³. Their mean age was 30±15 years (range: 15 months to 48 years). The average age of HIV-infected patients (36 years) was significantly higher than of those without HIV infection (15 years). Thirteen patients had symptoms, most frequently diarrhea (11 cases), sometimes associated with dehydration (5 cases). Eight patients (57%) received only symptomatic treatment, and 4 (28.6%) received albendazole. No treatment was recommended in 2 cases (14.3%). Clinical course was marked by improvement in 6 cases, death in 5, and persistence of asymptomatic carriage in one. Two patients were lost to follow-up. Conclusion: Intestinal microsporidiosis is a parasitological disease that mainly affects AIDS patients with CD4 counts <\;100 cells/mm ³. Its diagnosis requires special techniques. Its symptomatology is dominated by chronic diarrhea that can cause dehydration. Effective treatment requires identification of the species.
Keywords : diagnosis, epidemiology, microsporidiosis, Tunisia