|
|
 |
 |
| |
 Printable version |
TNF α in infectious diseases: present position and future perspectives. |
Cahiers d'études et de recherches francophones / Santé . Volume 1, Number 5, 357-60, Décembre 1991, Synthèse
|
 Résumé
Article gratuit
|
Author(s) : Jean-Étienne Touzé, Fabrice Simon, Philippe Hovette, François Peyron, Michel Le Bras, Roland Laroche |
Summary : Tumour necrosis factor (TNF) or cachectin is a cytokine produced by human monocytes and macrophages. It has long been known for its anti-tumoural properties, but its role in infectious diseases was recognized more recently. TNF has benificial and protective actions against infectious agents, stimulating phagocytosis, activating eosinophils, interventing in bacterial killing and protecting against fungi and viruses. However, TNF can have harmful effects on the host, mediating septic shock, and playing a role in the onset of malarial complications. Its synthesis is controlled in a complex way and involves numerous mediators, including prostaglandins, interleukins, and gamma interferon. TNF can be assayed on the basis of its biological activities: antibodies to TNF α, association γ interferon and TNF α. |
Keywords : |
|
