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Serology of toxoplasmosis and cytomegalovirus of HIV-seropositive patients in Congo |
Cahiers d'études et de recherches francophones / Santé . Volume 4, Number 1, 15-9, Janvier-Février 1994, Étude originale
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 Résumé
Article gratuit
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Author(s) : Maria Makuwa, Hugues Loemba, Jacques Ngouonimba, Yves Beuzit, Jean-Paul Louis, Jean-Michel Livrozet |
Summary : Cerebral toxoplasmosis and cytomegalovirus (CMV) infection are very frequent in AIDS. Biological markers of toxoplasmosis and CMV were studied in blood and cerebrospinal fluid (CSF) of 121 HIV-positive and 35 HIV-negative patients in the Central Hospital of the Congolese Army in Brazzaville. In the case of clinically suspected cerebral toxoplasmosis, the simultaneous presence of specific IgG antibodies in the blood and in the CSF can be considered as having complementary diagnostic value (PPV \= 63.3%, NPV \= 89.9%). The symptomatology of AIDS is very polymorphous and includes various etiological factors\; as a result it is very difficult to estimate the responsibility of cytomegalovirus in the absence of positive viral culture, even with the simultaneous presence of specific IgG antibodies in the blood and CSF (PPV \= 75.7%, NPV \= 54.6%). |
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