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 Printable version |
Perchlorates and nitrates: Little known or relatively neglected toxicants? |
Environnement, Risques & Santé. Volume 9, Number 2, 159-64, mars-avril 2010, Note technique
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 Résumé
Article gratuit
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Author(s) : Roland Masse, Claude Boudène |
Summary : Iodine deficiency is a worldwide issue that has not spared Europe. Its health consequences and especially its adverse effects on the growth and development of fetuses, infants, and children are well known. Perchlorates and nitrates impair iodine uptake in the thyroid gland by competitive inhibition of iodine symporter and thus merit the attention paid to other endocrine disruptors, an attention they have not yet received in France. In the US a reference dose of 0.07 to 0.7 μg/kg has been proposed for perchlorates, which would result in a safe limit of 1.5 to 15 μg/L of water, after consideration of a safety factor of 10 for fetus and infants. Because nitrate ions, while 240 times less effective than perchlorates, are more than 1 000 times more abundant, elevated nitrate concentrations in some surface waters are a matter of concern, and some French subpopulations with iodine deficiency may be at risk. Moreover, an inventory of perchlorate exposure should be planned. |
Keywords : endocrine disruptors, iodine deficiency, nitrates, perchloric acid, thyroid gland |
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