Médecine thérapeutique / Pédiatrie
MENUTumour lysis syndrome Volume 19, issue 2, Avril-Mai-Juin 2016
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- Key words: lysis syndrome, hyperphosphataemia, hypocalcaemia
- DOI : 10.1684/mtp.2016.0598
- Page(s) : 112-6
- Published in: 2016
The identification of patients at risk of lysis syndrome, which represents a life-threatening emergency, can lead to the establishment of preventative treatment measures. With regards to phosphocalcic metabolism, the release of intracellular electrolytes is directly responsible for hyperphosphataemia. Acute hyperphosphataemia leads to a precipitation of calcium phosphate crystals in the soft tissues and, consequently, to hypocalcaemia. These precipitations may occur in any soft tissue of the body, including the heart and kidneys. Vigorous hydration, accompanied by close monitoring of diuresis, represents the cornerstone of treatment for lysis syndrome. The preventative use of recombinant urate oxidase in high-risk patients has significantly improved the prognosis of lysis syndrome.