John Libbey Eurotext

Médecine thérapeutique / Médecine de la reproduction, gynécologie et endocrinologie


Developmental Origins of Health and Diseases and reproduction Volume 13, issue 4, Octobre-Décembre 2011

AP-HP, hôpital Jean-Verdier, histologie-embryologie-cytogénétique-CECOS, 93143 Bondy, France, Université Paris 13, unité de recherche en epidémiologie nutritionnelle, UMR U557 Inserm, U1125 Inra, Cnam, CRNH IdF, 93017 Bobigny, France, Inra, UMR 1198 biologie du développement et reproduction, 78350 Jouy-en-Josas, France, ENVA, F-94704 Maisons-Alfort, France
  • Key words: DOHaD, nutrition, reproduction, epigenetic
  • DOI : 10.1684/mte.2011.0375
  • Page(s) : 265-74
  • Published in: 2011

Nutritional maternal imprinting is a well known process, included in DOHaD (Developmental Origins of Health and Diseases) concept. Maternal environment during periconceptional and foetal period may alter structure and/or functions of many organs and/or cells of the conceptus and predispose offspring to further develop pathologies, such as metabolic disorders. Epidemiological study and experimental data in animals have highlighted that maternal malnutrition during periconceptional and foetal period may also impact on reproductive functions of male and female offspring. Effects of maternal nutrition have been observed as soon as foetal stage on gonadal differentiation and development. It also impacts on onset of puberty, gamete quality, hormonal status and fertility in adulthood. Mechanisms involved in these phenomena are not completely understood. However, maternal hormonal status in periconceptional period, oxidative stress and epigenetic imprinting are likely to play a critical role.