John Libbey Eurotext

Médecine de la Reproduction

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Uterine transplantation : which indications ? Volume 15, issue 2, Avril-Mai-Juin 2013

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UMPC Université Paris 6 et AP-HP Groupe hospitalier universitaire de l’Est parisien, Service de Gynécologie Obstétrique et Médecine de la Reproduction, Hôpital Tenon, 4 rue de la Chine, 75970 Paris Cedex 20, France

Permanent uterine infertility might be treated by transplantation of the uterus in young women seeking pregnancy, without any problem for pregnancy or transplantation, and normal or slightly altered ovarian reserve. The best indications are uterine agenesis (Mayer Rokitansky Kuster Hauser syndrome), emergency hysterectomy for severe bleeding after delivery or caesarean section, for necrosis after embolization, or hysterectomy due to multiple myomas, cervical or uterine cancer (endometrial or sarcoma). The womb may also be present but unable to implant because of Müllerian severe malformations, multiple fibroids, severe adenomyosis, fibrous adhesions or previous radiotherapy.