JLE

Médecine de la Reproduction

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Impact of endometrial abnormalities on fertility Volume 23, issue 1, Janvier-Février-Mars 2021

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Authors
1 Service clinico-biologique d’assistance médicale à la procréation, CMCO Schiltigheim, Hôpitaux Universitaires de Strasbourg
2 Service de gynécologie obstétrique, CMCO Schiltigheim, Hôpitaux Universitaires de Strasbourg
* Tirés à part

Endometrial abnormalities are particularly evident in women of chidbearing age. Endometrial disorders have an impact on embryonic implantation and pregnancy progression. Their research is often done upstream of any management in case of infertility, and secondarily in failures to obtain pregnancy or repeated miscarriage. To date, there is no real “evidence-based medecine” on their management, even if professionnals agree to treat as soon as they have knowledge. We will see successively the impact of polyps, uterine dysmorphia and isthmocele then, from more microscopic point of view, the relevance of uterine thickness, the dangerousness of endometrial hyperplasia and the insidious nature of chronic endometritis. The recent revelation of the microbiota in the balance of organ functions, its impact on the efficiency of organ activity and whether or not certain pathologies are revealed, forces us to revisit our knowledge and understanding of certain unexplained situations so far. However, if each context is responsible for certain implantation failures or obstetric complications, it can only be directly concerned if the preimplantation embryo is itself of good quality and euploid.