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Magnesium Research

Analysis of the effect of perioperative magnesium sulphate on minimal alveolar concentration of desflurane using bispectral index monitoring Volume 24, issue 4, December 2011

Résumé : <p>In this study we aimed to analyze the effect of perioperative magnesium sulphate (MgSO 4) on minimal alveolar concentration (MAC) of desflurane using bispectral index (BIS) monitoring.</p><p>Sixty patients undergoing abdominal surgery under general anesthesia were randomized into two groups: Mg – receiving perioperative MgSO 4 supplementation and C – control. Anesthesia was titrated to maintain the BIS value between 45-55.</p><p>MAC values, tachycardia and hypertension during intubation was found to be lower in group Mg compared to group C (p<0.001). Time to extubation, verbal cooperation and eye opening was longer in patients receiving infusion of MgSO 4 (p<0.001).</p><p>We concluded that perioperative MgSO 4 infusion may be used as an adjunct as it decreases MAC of desflurane and suppresses the hemodynamic response to intubation.</p>