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 Printable version |
Update on the genetic risk factors for venous thrombosis |
Sang Thrombose Vaisseaux. Volume 22, Number 8, 421-7, octobre 2010, Mini-revue
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 Résumé
Texte intégral
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Author(s) : Pierre-Emmanuel Morange, Joseph Emmerich, David-Alexandre Tregouet |
Summary : Venous thrombosis (VT) is a frequent disorder affecting ~0.2% of individuals a year and associated with a mortality rate of 10%. It is well admitted that VT is a multifactorial disease resulting from the interplay of environmental and genetic factors with an estimated heritability of ~60%. Until the beginning of 2000s, well-established genes involved in VT susceptibility include factor V (FV), factor II (FII), protein C (PC), protein S (PS), antithrombin (AT). Only less than 30% of idiopathic (i.e without any environmental origin) VT patients and one-third of patients with a positive family history of VT carry known identified genetic variants. This suggests that other genes are involved in susceptibility of VT. Some of them have been recently identified by the new technological tools available now in the field of genetic research. This review can be considered as an update of what is known today on the genetic risk factors for VT. |
Keywords : venous thrombosis, risk factor, genetics |
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