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 Printable version |
Gadolinium chelate toxicity in renal failure |
Sang Thrombose Vaisseaux. Volume 22, Number 2, 90-5, février 2010, Mini-revue
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 Résumé
Texte intégral
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Author(s) : E Ledneva, N Janus, S Amet, V Launay-Vacher, G Deray |
Summary : Gadolinium (Gd) chelates are contrast media used during magnetic resonance imaging procedures. Initially, these drugs were regarded as well-tolerated and non-nephrotoxic. However, several studies reported cases of nephrotoxicity induced by Gd based contrast media, in the majority of cases used at doses higher than 0.2 mmol/kg for diagnostic or interventional angiographic procedures after intra-arterial administration in patients with pre-existing renal insufficiency. The mechanism responsible for this nephrotoxicity is not clearly understood and remains a subject of debate. In addition, several Gd chelates appear to be responsible for a rare but severe side effect in chronic renal failure patients: nephrogenic systemic fibrosis. This side effect appears to be related to the use of some Gd chelates which under certain conditions become unstable and release Gd from its chelate, resulting in nephrogenic systemic fibrosis. However, the risk factors of this disease are not yet known, with the exception of pre-existing renal failure. The risk seems higher with some gadolinium chelates than with others. The object of this review is to describe the possible undesirable renal effects of Gd based contrast media, and to summarise recent data on nephrogenic systemic fibrosis. |
Keywords : gadolinium chelates, renal insufficiency, nephrogenic systemic fibrosis |
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