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Cell therapy and acute ischaemic stroke |
Sang Thrombose Vaisseaux. Volume 22, Number 2, 72-8, février 2010, Mini-revue
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 Résumé
Article gratuit
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Author(s) : O Detante, C Remy, M Hommel, M-J Richard |
Summary : Stroke is the leading cause of acquired adult disability. With the exception of admission to hospital stroke units, only thrombolysis administered within the first hours of the onset has been shown to be effective in the treatment of acute ischemic stroke within the first hours after the onset. Increasing brain plasticity after stroke represents an important alternative strategy. Cell therapy using stem cell administration provides a functional improvement after cerebral ischemia in rodent models. This “restorative” therapy aims at replacing destroyed cerebral tissue with a stem cell graft. From bench to bedside, the pioneer clinical studies were limited to a small number of patients. Despite promising results, we do not know yet the best blend of stem cell, the best route of the stem cell administration, the best dose and the optimal delay of the graft remain unknown. New clinical trials of autologous cell therapy after stroke have started. These trials have to be conducted with the parallel development of experimental studies to improve our knowledge of the effects of this promising therapy for stroke. |
Keywords : stroke, cell therapy, stem cell |
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