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 Printable version |
Serum amyloid A: a major inflammatory apolipoprotein. |
Sang Thrombose Vaisseaux. Volume 20, Number 7, 362-8, Juillet 2008, Mini-revue
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 Résumé
Article gratuit
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Author(s) : Christine Poitou, Adeline Divoux, Karine Clément |
Summary : Serum amyloid A (SAA) is an acute phase protein mainly produced by the liver under pro-inflammatory cytokine stimulation. SAA is involved in host defense and tissue repair and can increase from 100 to 1,000 fold of its normal value. This apolipoprotein changes the structure and function of inflammatory HDL particules. In vitro experiments showed that SAA is able to promote cholesterol efflux particularly from macrophages. Observational studies showed that elevated circulating levels of SAA is associated with peripheral and coronary arterial disease suggesting that SAA may be involved in atherosclerosis development. Adipocytes synthesize large amounts of SAA during obesity-related low-grade inflammation. However, the role of SAA in adipose tissue, especially in the interrelationship between adipocytes and inflammatory cells, remains to be elucidated. In vivo studies are now required to improve our knowledge of the role played by chronic low increases of SAA in obesity related-HDL dysfonction and their consequences on the arterial wall. |
Keywords : serum amyloid A, inflammation, HDL, cholesterol, macrophage, atherosclerosis, obesity |
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