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 Printable version |
Monogenic hypercholesterolemia in childhood : therapeutic strategies |
Sang Thrombose Vaisseaux. Volume 17, Number 9, 505-10, Novembre 2005, Mini-revue
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 Résumé
Article gratuit
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Author(s) : Valérie Carreau, Jean-Philippe Girardet, Eric Bruckert |
Summary : Familial hypercholesterolemia is the most common genetic abnormality. Although a majority of patients are asymptomatic, they may suffer atherosclerosis during childhood. Systematic screening is therefore warranted in children with a family history of premature cardiovascular disease (CVD). Cholesterol studies performed in a large cohort of French children showed similar patterns to other European countries. A genetic diagnostic is useful to clearly identify these patients at high risk of premature CVD. New tools are now available to measure premature arterial dysfunction (endothelial dysfunction) and increase of intima media thickness (IMT). |
Keywords : familial hypercholesterolemia, systematic screening, intima media thickness, genetic diagnosis |
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