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 Printable version |
Specific Cox-2 inhibitors and haemostasis |
Sang Thrombose Vaisseaux. Volume 14, Number 3, 147-52, Mars 2002, Mini-revues
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 Résumé
Article gratuit
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Author(s) : Eric Hachulla, Brigitte Jude, Ulrique Pasturel-Michon |
Summary : The development of Cox-2 inhibitors as anti-inflammatory agents without gastric toxicity is based on the premise that Cox-1 predominates in the gastric mucosa. However, selective Cox-2 inhibitors decrease vascular prostacyclin production and may affect the balance between prothrombotic and antithrombotic eicosanoids. Unlike the platelet inhibition provided by Cox-1 inhibitors. Cox-2 inhibitors do not have this antithrombotic property. High cardiovascular risk, patients need aspirin for cardioprotection. The association of Cox-2 inhibitors and aspirin partially reduces the gastro-intestinal benefits. Moreover, the concommitant administration of conventional nonsteroidal anti-inflammatory drugs may antagonize the irreversible platelet inhibition induced by aspirin. This risk does not exist when selective Cox-2 inhibitors are associated with aspirin. |
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