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 Printable version |
Homocystein and transplantation |
Sang Thrombose Vaisseaux. Volume 12, Number 8, 510-4, Octobre 2000, Mini-revues
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 Résumé
Article gratuit
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Author(s) : Pierre Ambrosi |
Summary : There is a very high prevalence of hyperhomocysteinemia (59 to 100%) in cardiac and renal transplant recipients and mean plasma homocysteine levels are nearly twice those of non-transplant controls. The main cause of this abnormality is renal failure related to ciclosporin nephrotoxicity. However, renal failure only explains part of the increased concentrations. A direct effect of ciclosporin on homocysteine metabolism has been suggested but not confirmed. The prevalence of hyperhomocysteinemia is significantly higher in cardiac transplant patients with coronary graft vasculopathy than in matched cardiac transplant recipient controls without vasculopathy. One report suggested that hyperhomocyteinemia predicted vascular complications in renal transplant patients.
The value of folic acid with or without vitamin B12 supplement therapy in transplant patients is still under investigation. On going clinical trials should provide the answer to this question. |
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