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 Printable version |
Role of the adventitia in post-angioplasty coronary restenosis |
Sang Thrombose Vaisseaux. Volume 10, Number 1, 12-9, Janvier 1998, Mini-revues
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 Résumé
Article gratuit
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Author(s) : Michael Maeng, Henning Rud Andersen |
Summary : This paper reviews our current understanding of restenosis pathophysiology. Restenosis was previously believed to be caused mainly by smooth muscle cells migrating from the media into the injured arterial surface thereby forming neointima. The concept of neointimal formation being due to cells migrating from media has been modulated by experimental studies in porcine coronary models of restenosis suggesting that adventitial cells may play an important role in neointimal formation. Furthermore, both clinical and experimental results strongly indicate that changes in arterial size, i.e. vascular remodeling, plays a role at least equal to that of neointimal formation. In addition in cases of vascular remodeling the adventitia may play a role by “constricting” the vessel, a phenomenon comparable to scar contraction in other organs. |
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