|
|
 |
 |
| |
 Printable version |
Oocyte and embryo: from morphology to gene expression therapy |
Médecine Thérapeutique / médecine de la reproduction. Volume 9, Number 6, 381-8, Novembre-Décembre 2007, Revue
|
 Résumé
Article gratuit
|
Author(s) : Samir Hamamah, Delphine Haouzi, Stephan Gasca, Frank Pellestor, Tal Anahory, John De Vos, Hervé Dechaud |
Summary : The embryo and pregnancy rates that are obtained after in vitro oocyte fertilization remains low, in conventional IVF (IVFc) as well as after ICSI. These failures of fecundation are more often associated with poor embryo quality that results itself from poor gamete quality. So far, gametes and embryos are selected on purely morphological criteria, thus subjective. The knowledge about gene expression within oocyte, cumulus cells and early embryo with the microarray technique should allow better considering and understanding the early oocyte and embryo development. Later on, this kind of approach will facilitate the identification of reliable markers of oocyte and embryo quality. The use of a genetic signature of oocyte and embryo quality should allow improving the success rate of IVFc and ICSI that are so far based exclusively on morphological criteria. |
Keywords : oocyte, embryo, cumulus, gene, selection criterium |
|
