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 Printable version |
Chromosomal abnormalities in human oocyte : formation, etiology and detection |
Médecine Thérapeutique / médecine de la reproduction. Volume 9, Number 6, 369-80, Novembre-Décembre 2007, Revue
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 Résumé
Article gratuit
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Author(s) : Frank Pellestor, Samir Hamamah |
Summary : The cytogenetic analysis of human oocytes has been then considered as a highly valuable source of data for the investigation of both the occurrence and the origin of chromosomal abnormalities in human. During the last 4 decades, the cytogenetic analysis of human oocytes has never stopped to progress, according to the advents of new technologies. Both karyotyping and then molecular cytogenetic studies based on in situ hybridization techniques, have been reported to date, providing a large body of data on the incidence and the distribution of chromosomal abnormalities in human female gametes. The most relevant analysis have led to the estimate that 15-20 % of human oocytes present chromosome abnormalities, and they have emphasized the implication of both whole chromosome nondisjunction and chromatid separation in the occurrence of aneuploidy in human oocytes. The effect of advanced maternal age on the incidence of aneuploidy in human oocytes has also been clearly evidenced by recent reports based on large sample of oocytes or polar bodies. |
Keywords : oocyte, meiosis, chromosomal abnormalities, maternal ageing |
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