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 Printable version |
Mesenchymal stem cells: from basic science to regenerative medicine |
MT / médecine de la reproduction, gynécologie et endocrinologie. Volume 11, Number 1, 46-54, janvier-février 2009, Revue
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 Résumé
Article gratuit
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Author(s) : L Casteilla, P Laharrague, P Bourin, L Sensébé |
Summary : Mesenchymal stem cells (MSCs) are of a great potential because they are easily isolated and expanded. Recently, several studies have reported that MSCs, well-characterized in bone marrow tissue, originated from pericytes. Cells with MSC properties are found in a variety of adult tissues, however with specific characteristics. They share an antigenic pattern, can differentiate into cells of the mesodermal lineage, support hematopoietic progenitors, and possess potent immunosuppressive properties. Numerous clinical trials are presently performed in very different fields, such as bone defects or immunomodulation. However, further many studies are needed to improve clinical trial designs and for the possible translation of MSCs to new therapeutic approaches. |
Keywords : mesenchymal stem cell, regenerative medicine, stroma |
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