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 Printable version |
Treatment of diabetes by cell therapy: new insights on stem cells and precursors |
MT / médecine de la reproduction, gynécologie et endocrinologie. Volume 11, Number 1, 35-45, janvier-février 2009, Revue
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 Résumé
Article gratuit
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Author(s) : Julie Kerr-Conte, Thomas Hubert, François Pattou |
Summary : Allogeneic transplantation of islets of Langerhans, based on the selective graft of endocrine islets of Langerhans, several mililiters of tissue isolated from nondiabetic subjects and infused in the portal vein, allows in the most experienced centers achievement of short-term results identical to pancreas transplantation (80% of insulin-independence at one year). Development of cell therapy of diabetes is crucial and is currently confronted with three major obstacles: immune rejection, the poor initial implantation of islets and the limited duration of their function in the recipient. The forseeable progress will lead to an extension of the indications in years to come to patients suffering from the most severe forms of type 1 diabetes. The structural shortage of organ donors limits however the development of primary islet allografts. Involvement in the production of insulin-secreting cells destined for transplantation in man represents an considerable stake for the treatment of diabetes by cell therapy and, in particular, by the proliferation of adult human islets, the exploitation of living and non-heart beating donors, the acquisition of xenogeneic islets, the proliferation and differentiation of stem cells and precursor/progenitor cells, and transdifferentiation. |
Keywords : islet, cell therapy, diabetes, insulin-secretion, stem cell, precursor cell |
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