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 Printable version |
Role of chemokines in atherosclerosis. Complementarity of clinical and fondamental research in the development of therapeutical strategies |
MT Cardio. Volume 2, Number 5, 561-70, Septembre-Octobre 2006, Revues
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 Résumé
Article gratuit
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Author(s) : Stéphane Potteaux, Alain Tedgui, Ziad Mallat |
Summary : Atherosclerosis is a chronic inflammatory disease of the arterial wall. In vitro analysis and mice models of atherosclerosis allow the understanding of mechanisms involved in this pathology. The development of atherosclerosis relies on the recruitment of leukocytes, especially monocytes and lymphocytes within the inflammed vessel wall. Immune cell attraction depends on chemokine-chemokine receptors interaction. In vitro studies have revealed the importance of IL-8/CXCR2, MCP-1/CCR2, fractalkine/CX3CR1, RANTES/CCR5 chemokines/receptors couples in the first steps of atherosclerosis, which consists of leukocyte adhesion to endothelial cells and leukocyte diapedesis towards the intima. Gene disruption analysis provides further explanation of the role of chemokines in atherosclerosis by showing their crucial role either on the growth or on the stability of atherosclerotic lesions. These studies in animal models allow a better understanding of the molecular mechanisms responsible for ischemic events, such as acute coronary syndromes, which occur in people presenting defined chemokine gene polymorphisms. Furthermore, thorough understanding of chemokine-dependant leukocyte trafficking provide a new pathway for therapeutic investigation in cardiovascular diseases. |
Keywords : atherosclerosis, chemokine, therapeutic strategy |
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