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Titre du document ici |
l'Information Psychiatrique. Volume 82, Number 5, 415-20, Mai 2006, Psychopharmacovigilance
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 Résumé
Article gratuit
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Author(s) : Pedro Valente |
Summary : The mnestic effects of ECT (electroconvulsive therapy): nature, aggravating factors, supposed mechanisms, therapeutic options.The mnestic effects of ECT are mainly resolutive, even if some periods of retrograde lacunary amnesia may persist. The bilateral placing of electrodes, the charge used, the number and the frequency of sessions can exacerbate these effects. The physiopathological hypothesis is that of a disturbance (especially in the region of the hippocampus) of long-term potentiation (LTP), not by inhibition, but by maximum saturation making all later learning or recalling impossible. This saturation would seem to be temporary thanks to the action of scavengers or antagonists, leading to a hope for a therapy based on the use of N-methyl-D-aspartate receptors. |
Keywords : ECT (electroconvulsive therapy), memory, long-term potentiation, N-methyl-D-aspartate |
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