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 Printable version |
Imaging of response to treatment in digestive oncology |
Hépato-Gastro. Volume 19, Number 3, 188-99, Mars 2012, Dossier Thématique : Évaluation de la réponse tumorale
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 Résumé
Texte intégral
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Author(s) : Maïté Lewin |
Summary : Imaging plays a crucial role in the evaluation of digestive tumors response to treatment. Up to date, morphological criteria are the gold standard. The criteria of the World Health Organisation (WHO) are based on the measurement of two orthogonal dimensions to get an estimate of the tumor's apparent area. The “Response Evaluation Criteria in Solid Tumors” (RECIST), more currently used, are based on the measurement of the largest dimension of the tumor. These criteria have been recently revisited (RECIST 1.1). However, new therapies currently developing, such as antiangiogenic drugs, suggest to focus instead on tumor hypervascular area (modified RECIST) or tumor density (Choi criteria). Moreover, new functional imaging approaches are being set up: dynamic contrast-enhanced imaging of tumor microvascularization that relies on vascular and interstitial distribution analysis of a contrast agent, diffusion-weighted magnetic resonance imaging (MRI), allowing tumor cellularity and microvascularization to be indirectly evaluated from the mobility of water molecules and positon-emission tomography (18 FDG PET), giving information on tumoral metabolic activity. |
Keywords : digestive cancer, therapeutic response, RECIST, dynamic contast-enhanced imaging, diffusion-weighted MRI, PET |
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