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Hématologie. Volume 17, Number 1, 24-39, Février 2011, Revue

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Author(s) : Amine Boudil, Vanessa Zepponi, Lamia Skhiri, Sophie Ezine

Summary : After the graft of hematopoietic stem cells, the reconstitution of the T cell lineage is very slow. This process is, thus, responsible of the absence of a major component of the immune system in these patients and of frequent deadly effects. Therefore, accelerating the reconstitution of the lymphoid T cell lineage would allow the restoration of an efficient immunity. T cell hematopoiesis present different characteristics compared to other lineages: progenitors and their products reside in different environments\; thus, various intermediates of differentiation are detected in many organs. Moreover, genes responsible of the T cell engagement and their coordination are not known. Importantly, the initiation of the T cell lineage from the hematopoietic tree is not solved. Thus, a better understanding of the factors and mechanisms involved in the generation of the T cell lineage will allow the control of its production in order to have access to new therapies.

Keywords : thymus, transcription factor, chemokine, progenitor