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 Printable version |
Tumor necrosis factor : from biology to anticancer therapy |
Hématologie. Volume 15, Number 4, 291-304, juillet-août 2009, Mini-revue
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 Résumé
Article gratuit
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Author(s) : Ahmed Hamaï, Jane Muret, Andrea Cavalcanti, Sylvie Bonvalot, Salem Chouaïb |
Summary : Tumor necrosis factor (TNF\; formerly known as TNF-α), isolated 30 years ago, is a pleiotropic cytokine playing a role in apoptosis and cell survival as well as in inflammation and immunity. Although named for its antitumor properties, TNF-α has been implicated in a wide spectrum of diseases including chronic inflammation, autoimmunity and cancer. This review provides an overview of current knowledge of TNF-signalling, its physiological implication in inflammation and its paradoxical role in tumor process. We review the experimental and clinical advances in TNF-based antitumor therapy underlying the complex and sometimes conflicting relationship between this cytokine, cancer and anticancer therapy. |
Keywords : TNF, apoptosis, cancer, isolated limb perfusion |
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