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 Printable version |
Hematopoietic stem cell transplantation in autoimmune disease. |
Hématologie. Volume 13, Number 6, 445-55, Novembre-Décembre 2007, Revue
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 Résumé
Article gratuit
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Author(s) : Zora Marjanovic, Laura Florea, Franck Verrecchia, Dominique Farge-Bancel |
Summary : Experimental considerations and clinical experience suggest that high doses immunoablation followed by hematopoietic stem cell transplantation (HSCT) is a therapeutic option to consider for certain severe autoimmune disorders. Patient selection has been recognized as a crucial element from the phase I-II trials. Improved safety of both autologous and allogeneic HSCT over the last decade has been followed by increasing acceptance of HSCT as an experimental treatment for severe autoimmune diseases that are resistant to conventional treatment. Prospective randomized studies are in progress and should now determine the value of HSCT compared to standard therapy. This review provides the update on the efficacy and toxicity of HSCT in severe autoimmune disease. |
Keywords : autoimmune disease, hematopoietic stem cell transplantation |
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